Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.

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Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses

We have examined the role of endogenously produced interleukin (IL) 4 and IL-10 in the regulation of inflammatory and immune reactions in the skin. In these experiments, irritant and contact hypersensitivity (CH) responses were elicited in mice with targeted disruptions of the IL-4 (IL-4T) or IL-10 (IL-10T) gene. Our study showed that IL-4T and wild-type (wt) mice exhibited equivalent responses...

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Background: Increased levels of interleukin-8 (IL-8) and interleukin-6 (IL-6) in acute human brucellosis have been reported. Previous studies have shown that the production and level of IL-6 and IL-8 cytokines are associated with the polymorphism of the encoding genes. Objective: To investigate the probable association between IL-6 (-174 C/G) and IL-8 (-251 A/T) gene polymorphisms and susceptib...

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Interleukin-4 but not gamma interferon production correlates with the severity of murine cutaneous leishmaniasis.

For murine cutaneous leishmaniasis, data to date suggest a correlation between the presence of gamma interferon (IFN-gamma) and resistance in C57BL/6 mice and the presence of interleukin-4 (IL-4) and disease in BALB/c mice. In this study, 13 inbred strains of mice covering the range of susceptibility to disease were infected with Leishmania major to determine whether the subsequent expression o...

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Interleukin-10 is a proliferation factor but not a differentiation factor for human myeloma cells.

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1995

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.182.1.99